Wales Tourism and Visit Planning

In their discussion of the findings, the authors remark that an increase in EPA would favor the synthesis of prostaglandins and leukotrienes have a lesser inflammatory effect than those synthesized by arachidonic acid, thus reducing the effects of inflammatory conditions such as rheumatoid arthritis or asthma which have a negative impact on physical well being. holiday in wales

The results from this population-based survey of New Zealanders suggest a strong and consistent association between eicosapentaenoic acid in serum phospholipids and self-reported physical well-being, the authors conclude. holiday wales

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November 16, 2007 caravan holiday in wales

New study finds association between vitamin D and lower endometrial cancer rates camping holiday wales

The November 16, 2007 issue of the journal Preventive Medicine reported the outcome of a study conducted at the University of California, San Diego s Moores Cancer Center which found an association between ultraviolet light exposure and a reduced risk of endometrial cancer. The study follows two previous investigations which linked a lower rate of kidney and ovarian cancer with greater ultraviolet exposure, which increases the formation of vitamin D3 in the human body. accommodation holiday wales

As in the preceding studies, UCSD School of Medicine professor of Family and Preventive Medicine Cedric F. Garland, DrPH and associates utilized data made available through GLOBOCAN, a database of cancer incidence and mortality in 175 countries. By plotting endometrial cancer incidence rates according to latitude, the team was able to observe an greater rate of the disease with increased latitude, which correlates with less sun exposure and lower vitamin D levels. In general, endometrial cancer incidence was highest at the highest latitudes in both hemispheres, Dr Garland stated. Even after controlling for known variables such as cloud cover, meat intake, weight, skin pigmentation and others, the association remained strong. holiday last minute wales

This is the first study, to our knowledge, to show that higher serum levels of vitamin D are associated with reduced risk of endometrial cancer, Dr Garland announced. Previous epidemiological studies have focused on estrogen levels either natural or through hormone replacement therapy which play the major role in development of the disease, and on fat intake, which plays a smaller role. Since most women cannot control their natural levels of estrogen, and very low levels of fat intake are not acceptable to most American women, this article provides evidence that vitamin D adequacy should be considered as part of a comprehensive program for prevention of this cancer. catering holiday self wales

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November 14, 2007 family holiday wales

The benefit of going green holiday riding wales

An article appearing online the week of November 12, 2007 in the Proceedings of the National Academy of Sciences revealed that nitrite found in leafy green and other vegetables can help protect the heart from injury. adventure holiday wales

This new appreciation of the health benefits of nitrite and nitrate is ironic, stated senior author Dr David Lefer of the Albert Einstein College of Medicine of Yeshiva University. They ve traditionally been regarded as toxic because they tend to form chemicals called nitrosamines, some of which are carcinogenic. But recent research has found no convincing evidence that nitrite and nitrate pose a cancer risk. holiday park south wales

Recent studies show that administering nitrite to animals, either intravenously or orally, can greatly limit the damage caused by a heart attack and the stress to tissue that follows due to reperfusion the return of blood to oxygen-starved heart muscle, Dr Lefer observed. We wondered if feeding animals much lower levels of nitrite and nitrate equivalent to what people can readily obtain from their diets could also provide protection from heart-attack injury. cottage holiday wales

Dr Lefer and his colleagues added nitrite to the drinking water of a group of mice for seven days while another group received a standard diet. To mimic a heart attack, blood flow to the heart was arrested for thirty minutes followed by reperfusion for 24 hours. When the animals hearts were examined, those that received nitrite had 48 percent less damage than animals that did not receive the compound. holiday in wales

Nitrite and the related compound nitrate play a role in the production of nitric oxide, which helps relax the blood vessels. In an experiment involving nitrate, which converts in part to nitrite, a benefit similar to the first experiment involving was found. holiday wales

Our study suggests that building up nitrite stores in heart muscle could spell the difference between a mild heart attack and one that causes lasting heart damage or death, Dr Lefer concluded. cottage holiday in wales

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November 12, 2007 camping holiday wales

Grape polyphenols slow Alzheimer s plaque formation accommodation holiday wales

Antiaging Therapies | Your guide to drugs and nutrients which have been proposed as therapies to slow and/or reverse human aging. holiday last minute wales

References | A complete listing of all the references from the expanded fourth edition of Disease Prevention and Treatment. catering holiday self wales

END TEMPLATE HTML CODE BOTTOM FOOTER Content Ends - Footer WTL Removed START OF SmartSource Data Collector TAG 1999-2003 NetIQ Corporation. All rights reserved. V6.1 $DateTime: 2003/09/30 11:23:29 $ $Revision: #5 $ END OF Data Collection Server TAG Life Extension Member Rewards Program: Welcome Description Categories Questions and Answers Terms and Conditions Content Fix Content

As a valued member of the Life Extension Foundation, you receive a wealth of invaluable benefits, such as the cutting-edge Life Extension magazine, toll-free access to a team of knowledgeable advisors, and incredible discounts on pharmaceutical-quality vitamins and supplements, available through the Buyers Club. holiday wales walking

And now, we re adding even more value to your Life Extension membership! As a thank you for your support, we are delighted to offer you a program of exciting benefits and discounts available through our partner companies below. Bookmark this page as our offers are continually being updated! family holiday wales

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In order to offer even greater advantages to your membership, Life Extension introduces the LE Vacation Club. In partnership with Caribbean Islands Travel, Life Extension has created a unique and convenient travel website that offers exclusive deals for members only. adventure holiday wales

At LE Vacation Club you ll discover more than 100 specially discounted vacation packages and cruises including USA, Hawaii, Canada, the Caribbean, Mexico, Asia, South and Central America, and Europe. You ll also find suggestions for great vacation getaways, travel tips, hot deals, and links to the most important cruise lines all at your fingertips! You can even enjoy savings on specific travel products such as tours, charters, and excursions. holiday park south wales

This comprehensive and easy-to-use website also allows you to purchase airline tickets, reserve cars, and make hotel reservations online quickly and easily. cottage holiday wales

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If you can dream it, the Life Extension Foundation Platinum Plus MasterCard credit card with WorldPoints rewards can make it happen. cottage holiday in wales

We couldn t be more proud to offer you this exciting new credit card rewards program at competitive rates. Rich Rewards, World-Class service, Exceptional Benefits. The NO ANNUAL FEE* card has everything you d want in a card and much more! For more information or to apply call the toll-free number at 1-866-438-6262. caravan holiday in wales

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Hertz Rental Car Benefits for Life Extension Foundation Members accommodation holiday wales

Hertz operates in over 150 countries from 7, 200 locations worldwide. By using your LEF/Hertz discount CDP# 1507805 each time you place a reservation, you instantly qualify for member discounts in the U.S. and around the world. holiday last minute wales

For low web rates, special offers and free membership to our Hertz #1Club , visit www.hertz.com or call (800) 654-2200. catering holiday self wales

LEF and Bally Total Fitness are partnering to get you into shape! holiday wales walking

Mention Corporate ID# 2000035841 and receive 15% off any fitness membership plan level Platinum or higher. family holiday wales

Bally Total Fitness is the largest fitness center operator in the US, with about 420 gyms in 29 states, 70 US cities and Toronto. Bally offers quality service and outstanding facilities to help you achieve quick and long term results. holiday riding wales

For more information on Bally Total Fitness Centers, locations nearest you, and the membership plans available, visit www.ballyfitness.com or call 1-800-515-CLUB. adventure holiday wales

*Discount applies only to new fitness plans. holiday park south wales

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For just $9.95/month, LEF is proud to offer you a comprehensive medical discount card which will allow you to receive discounts ranging from 10-50% off on six primary health services - prescription drugs, dental services, vision services, chiropractic services, hearing services, and physician services. holiday in wales

Simply present your Life Extension Medical Discount Card to participating providers and receive your savings. By signing up for your LEF Medical Discount Card, you are gaining access to a national network of over 400, 000 participating credentialed providers, as well as a comprehensive network of pharmacies including CVS, Walgreen s, and Osco. holiday wales

Fruit extracts. cottage holiday in wales

Life Extension Mix is also fortified with fruit extracts such as bilberry, grape seed, grape skin, and citrus bioflavonoids to provide healthy circulation throughout the body and maintain healthy DNA.* caravan holiday in wales

The media has publicized the multiple benefits of fruits such as blackberry, cranberry, elderberry, cherry, plums and persimmon. Life Extension Mix has a customized blend of these and other fruits that studies indicate provide multiple favorable effects in the body. camping holiday wales

Olive oil consumption is one of the important factors behind the health benefits of the Mediterranean Diet. 16, 17 Researchers have discovered that there are up to 300 times more polyphenol compounds in olive water compared to olive oil. 18, 19 Olive polyphenols have been the subject of numerous studies pointing toward their benefits in many different areas, including helping to protect against LDL oxidation, suppressing free radicals, and stabilizing cell membranes. 20-22 Life Extension Mix contains a potent olive juice extract standardized to contain 7 percent of the best-documented polyphenol called hydroxytyrosol. 23 The amount of hydroxytyrosol in Life Extension Mix is equivalent to drinking one ounce of virgin olive oil per day. 24-25 accommodation holiday wales

Sesame lignans enhance the effects of vitamin E. Sesame and its lignans have a broad range of applications in human health. This includes increasing human tissue levels of vitamin E by facilitating carrier proteins in the liver to deliver nutrients to cells throughout the body. 26, 27 holiday last minute wales

Sesame lignans increase the anti-inflammatory index of fish oils and help maintain healthy cholesterol/LDL levels in those already within normal range.* 28-31 Life Extension Mix contains 10 mg sesame lignan extract to provide the direct benefits of the lignans and augment the effects of vitamin E and other nutrients in the body such as gamma-tocopherol and gamma-linolenic acid (GLA). catering holiday self wales

High potency vitamin D3. Doctors used to be concerned that too much vitamin D could be toxic. Over the past few years, however, an increasing body of evidence indicates that it takes much higher doses of vitamin D (perhaps over 10, 000 IU/day) to inflict toxicity on a healthy person. The concern expressed by researchers today is that fear of vitamin D toxicity is keeping many people from supplementing with enough vitamin D, which is critical for maintaining bone density. In response to studies showing that even those who take standard vitamin D supplements are not obtaining adequate amounts, Life Extension Mix provides 800 IU vitamin D3 per daily dose. holiday wales walking

Life Extension Mix saves time and money by combining the most popular nutrient supplements in one product, eliminating the need to take separate bottles of B-complex, vitamins C and E, mineral supplements and much more that would be required to achieve the same effects. Life Extension Mix supplies the most powerful antioxidants, including water and fat soluble vitamin C, the ideal form of alpha vitamin E, and plant extracts that help protect against cellular DNA damage. Other ingredients in Life Extension Mix enhance beneficial DNA methylation patterns, and help maintain glycemic control and healthy levels of LDL in those already within normal range.* family holiday wales

Life Extension Mix is the cornerstone of a comprehensive supplement program because it provides so many well-studied nutrients. If you are on a budget, Life Extension Mix provides the best cost per milligram value. With the addition of the newest ingredients, Life Extension Mix has become an even greater value. holiday riding wales

References

Supplement Facts adventure holiday wales

Serving Size 9 tablets (per day) holiday park south wales

Servings Per Container 35 cottage holiday wales

Amount Per Serving holiday in wales

Vitamin A (as 20% Betatene D. salina natural beta- holiday wales

5000 IU cottage holiday in wales

carotene with mixed carotenoids 1 and 80% acetate) caravan holiday in wales

Vitamin C (as ascorbic acid, calcium ascorbate, ascorbyl camping holiday wales

2000 mg accommodation holiday wales

palmitate, magnesium ascorbate, niacinamide holiday last minute wales

ascorbate, and acerola juice powder) catering holiday self wales

Vitamin D3 (as cholecalciferol) holiday wales walking

800 IU family holiday wales

Vitamin E (as D-alpha tocopheryl succinate) holiday riding wales

400 IU adventure holiday wales

Thiamine (vitamin B1) (as thiamine HCl) holiday park south wales

125 mg cottage holiday wales

Riboflavin (vitamin B2) holiday in wales

50 mg holiday wales

(with 2 mg riboflavin 5 phosphate coenzyme) cottage holiday in wales

Niacin (vitamin B3) (as 53% niacinamide, 38% niacin, caravan holiday in wales

862 mg camping holiday wales

9% niacinamide ascorbate) accommodation holiday wales

Vitamin B6 (as pyridoxine HCI with 2.5 mg pyridoxal 5 holiday last minute wales

100 mg catering holiday self wales

phosphate coenzyme) holiday wales walking

Folic acid family holiday wales

800 mcg holiday riding wales

Vitamin B12 (as 42% cyanocobalamin, adventure holiday wales

600 mcg holiday park south wales

42% hydroxylcobalamin, 16% ion exchange resin) cottage holiday wales

Biotin holiday in wales

3000 mcg holiday wales

Pantothenic acid cottage holiday in wales

600 mg caravan holiday in wales

(as D-calcium pantothenate with 5 mg pantethine) camping holiday wales

Calcium (as calcium ascorbate, D-calcium pantothenate, accommodation holiday wales

218 mg holiday last minute wales

Calcium D-Glucarate 2 ) catering holiday self wales

Iodine (as potassium iodide) holiday wales walking

75 mcg family holiday wales

Magnesium (as magnesium oxide, citrate, glycinate, holiday riding wales

400 mg adventure holiday wales

taurinate, arginate, ascorbate) holiday park south wales

Zinc [as methionate (OptiZinc 3 ), zinc succinate] cottage holiday wales

35 mg holiday in wales

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DCSIMG Home

| Membership | Products | Magazine | Health Concerns | News cottage holiday in wales

Le Magazine, September 2007 - Report: Wall Street Journal Attacks Flawed Fda Policies

The following reprint reveals in detail how the FDA not only fails to follow its own scientific protocols, but also flagrantly violates the fundamental right of an individual to pursue life free of undue government interference. caravan holiday in wales

We are reprinting (with permission) the entire Wall Street Journal editorial titled Drug Czars to provide a glimpse into what respected establishment publications are saying about the FDA s refusal to allow seriously ill Americans to use drugs that might save their lives. camping holiday wales

The Food and Drug Administration recently argued in the D.C. Court of Appeals that it has the power to ban meat and vegetables without violating anyone s fundamental rights. The agency chose this bizarre position in an attempt to counter arguments made by patients and their advocates in Abigail Alliance v. von Eschenbach. This groundbreaking case challenges the agency s refusal to grant access to investigational drugs, even as a last resort for terminally ill patients. accommodation holiday wales

Last year, a three-judge panel decided that the FDA is violating the due-process rights of terminally ill patients by denying them access to promising investigational drugs. In response the FDA moved for a rehearing by the full court, hoping to prevent a lower court-supervised examination of whether its draconian policies actually serve a narrowly tailored compelling governmental interest. In layman s terms, this means the FDA would have to show its policies toward terminal patients are so critical to the well-being of society that they supersede (in broad and highly imperfect fashion) the fundamental right of an individual to pursue life free of undue government interference. The FDA knows their policies will not survive this test, and doesn t want the question asked. holiday last minute wales

Consider the FDA s handling of Genasense , a new drug for melanoma and chronic lymphocytic leukemia (CLL), two often terminal forms of cancer. The drug is being developed by Genta, a small, innovative company with only one approved drug and limited financial resources. Despite compelling evidence that Genasense is making progress in fighting both diseases, the FDA appears determined to kill the drug. catering holiday self wales

In the case of the melanoma application, instead of reviewing the clinical-trial data in accordance with usual methods (which showed positive results), the FDA chose a nonstandard statistical approach aimed at discrediting the results. The agency used this analysis in its briefing to its advisory committee, claiming that the drug might not be effective. The committee then relied on that information to vote against approval. holiday wales walking

Now, Genta has found a serious mathematical error in the FDA s analysis, rendering its results meaningless. Genta is filing a complaint under the Federal Data Quality Act to correct the record. But in the meantime, the drug remains unapproved and melanoma patients continue to wait. family holiday wales

Genasense was also shown in a well-run, randomized clinical trial (the FDA s gold standard) to cause a complete disappearance of disease in 17% of patients with advanced CLL when combined with two older drugs. Just 7% of patients in a control group who received only the older drugs experienced similar benefit. The responders to Genasense have seen their relief last an average of 36 months, while those using other drugs saw their cancer return, on average, in 22 months. holiday riding wales

Following these results, the Director of the FDA s cancer division, Dr. Richard Pazdur, again convened a public meeting of his advisory committee. After an agency presentation designed to elicit a negative outcome, the panel voted 7 to 3 against approval, triggering an immediate reaction of surprise and dismay among many CLL experts. adventure holiday wales

But the committee vote is less surprising if one knows that the FDA appointed several voting consultants to the committee (none of them CLL experts), and recused from the meeting the only sitting member of the committee who is an expert in CLL. Perhaps even more troubling, two of the voting committee members worked behind the scenes as undisclosed consultants for the FDA on Genasense , then without disclosure voted in the open meeting. holiday park south wales

A shocked Genta quickly requested a meeting with the FDA to seek clarity on the agency s position, and to present additional information from patient follow-up. On the referral of an eminent leukemia expert, Genta asked if we would attend the meeting as witnesses in our capacity as patient advocates. No compensation was offered, requested or received. cottage holiday wales

• Selenium is required for proper functioning of the immune system (Look MP et al 1997). It is also essential in the synthesis of glutathione. Selenium s many benefits include protecting the central nervous system from dementia caused by HIV (Shor-Posner G et al 2002a) and infection with Mycobacterium tuberculosis (Shor-Posner G et al 2002b); slowing the loss of T-cells (Look MP et al 1997); and decreasing the effect of inflammatory cytokines, which may reduce the risk of developing neurological damage (Bjugstad KB et al 1998; Ryan LA et al 2001; Seilhean D et al 1997), Kaposi s sarcoma (a common HIV-associated cancer), and wasting syndrome. Selenium also suppresses the enhancing effect of cytokines on HIV replication (Hori K et al 1997; Tolando R et al 2000). holiday in wales

• Vitamin C and N-acetylcysteine

  Vitamin C (ascorbic acid) and N-acetylcysteine (Renis HE 1975) have multiple benefits in patients with HIV/AIDS. They maintain glutathione levels (Fawzi WW et al 2004; McComsey G et al 2003), improve T-cell counts and reduce viral load in patients who have advanced AIDS (McComsey G et al 2003; Standish LJ et al 2001; Tantcheva LP et al 2003), and have a toxic effect on HIV-infected cells (high levels of vitamin C) (Harakeh S et al 1991; Rivas CI et al 1997). Supplementation with N-acetylcysteine is recommended for people who are infected with HIV, whether or not they are receiving HAART. holiday wales

• Whey

  Whey protein contains all essential and nonessential amino acids, which are important to maintaining an adequate immune system response. Whey is also an important supplement to help boost the body s synthesis of glutathione, and clinical trials have successfully used whey protein in treating HIV (Marshall K 2004). Whey protein appears to be unique among proteins in its ability to improve immune function, elevate cellular glutathione levels, and maintain muscle mass (Marshall K 2004; Micke P et al 2002). cottage holiday in wales

Boosting the Immune System

In addition to boosting blood levels of antioxidants, studies have shown that it is helpful to include dietary supplements that directly enhance the immune system. Nutrients that have been documented to boost immune function include: caravan holiday in wales

• CoQ10

  People infected with HIV are often deficient in this important substance. CoQ10 is found in high concentrations in the healthy heart, where it improves cardiac function. CoQ10 also increases a number of immune parameters, including T-cell counts (Folkers K et al 1991; Yamashita S et al 1997). camping holiday wales

• L-carnitine

  . Also recommended as an antioxidant, L-carnitine boosts immune function to protect the heart against zidovudine toxicity (Mutomba MC et al 2000). L-carnitine can also protect against an increased level in triglycerides that is associated with protease inhibitors. High doses of L-carnitine enhance immunological and metabolic functions (Evangeliou A et al 2003). L-carnitine helps preserve T-cells by inhibiting cell death (Cifone MG et al 1997). accommodation holiday wales

• L-glutamine

  . In addition to its important role as an antioxidant, the amino acid L-glutamine plays a major role in the overall health of the gastrointestinal tract. Cells in the gastrointestinal tract have high energy requirements; glutamine is converted into adenosine triphosphate, which is a primary energy source (Alverdy JC 1990; Newsholme EA et al 1985; Souba WW et al 1985). Supplementation of antioxidants and glutamine increases body weight and cell mass. Thus, it provides a highly cost-effective therapy for the rehabilitation of patients infected with HIV who are losing weight (Shabert JK et al 1999). holiday last minute wales

• Vitamin B12

  . Studies have shown that patients with AIDS have a vitamin B12 deficiency as a result of severe nutrient malabsorption (Ehrenpreis ED et al 1994; Remacha AF et al 1991). Vitamin B12 deficiency is associated with reduced red blood cell count, depression, memory loss, insomnia, impotence, and lowered energy. If supplementation does help restore normal levels of vitamin B12, weekly injections may be indicated (Rule SA et al 1994). catering holiday self wales

• Zinc and magnesium

  . On average, patients with HIV/AIDS who have low zinc levels have a higher viral load and lower T-cell counts (Ferencik M et al 2003; Rousseau MC et al 2000). While on HAART, the conditions of patients with HIV should be monitored for zinc deficiencies, and supplements recommended when necessary (Wellinghausen N et al 2000). Additionally, low magnesium levels are related to HIV symptoms and disease progression (Patrick L 2000 Feb; Skurnick JH et al 1996). holiday wales walking

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